Appalachia is a geographic region located in the central and southern sections of the Appalachian Mountains of the eastern United States. In the north, its boundaries stretch from the western Catskill Mountains of New York, continuing south through the Blue Ridge Mountains and Great Smoky Mountains into northern Georgia, Alabama, and Mississippi, …Appalachia is a geographic region located in the central and southern sections of the Appalachian Mountains of the eastern United States. In the north, its boundaries stretch from the western Catskill Mountains of New York, continuing south through the Blue Ridge Mountains and Great Smoky Mountains into northern Georgia, Alabama, and Mississippi, with West Virginia near the center, being the only state entirely within the boundaries of Appalachia. In 2021, the region was home to an estimated 26.3 million people, of whom roughly 80% were White.