The San Francisco 49ers are poised to be underdogs for the first time since 2022, breaking a chain of 36 consecutive regular-season games in which they've been favored, the third-longest such ...

GREEN BAY, Wis. (AP) After losing to San Francisco in the playoffs three of the last five seasons, the Green Bay Packers wouldn’t mind seeing the 49ers get left out of the postseason entirely.

LATEST Nov. 22, 2:15 p.m. The 49ers will be without both quarterback Brock Purdy (shoulder) and defensive end Nick Bosa (hip and oblique injuries) for Sunday’s game against the Packers.

SANTA CLARA, Calif. — A San Francisco 49ers team that routinely rolled to big victories in 2023 can’t seem to pull away from anyone this season. They have no knockout punch. In Week 8 ...

The San Francisco 49ers needed a win Sunday at Levi's Stadium against the Seattle Seahawks. Instead, they turned in a dud that saw a disjointed offense plagued by mistakes, wasting a strong ...