Atherosclerosis is a chronic inflammatory process accounting for increased cardiovascular and cerebrovascular morbidity and mortality. A wealth of recent data has implicated several infectious ...

In atherosclerosis, the vascular smooth muscle cell (VSMC) contributes to vessel wall inflammation and lipoprotein retention, as well as to the formation of the fibrous cap that provides stability ...

Atherosclerosis is the build-up of fatty material (such as cholesterol), fibrous material and calcium). The build-up forms an atheroma (degeneration of the walls of the arteries) under the ...

Inflammation has an important role in the pathology of atherosclerosis. Glutaminase-2 (GLS2) is crucial for glutamine metabolism and its deficiency causes increased plasma glutamine levels ...

There is no US Food and Drug Administration (FDA)-approved therapy for NASH, and, like atherosclerosis, its progressive pathology is largely irreversible. “As with atherosclerosis, the ...

Subset analysis of FASCINATE-2 Phase 2 trial demonstrated denifanstat improved fibrosis in difficult-to-treat MASH patients ...

Sagimet Biosciences (SGMT) announced the presentation of Phase 2b data demonstrating the anti-fibrotic activity of its fatty acid synthase ...

FASN inhibitor treatment reduced atherosclerosis development in mouse model of dyslipidemia ... “Using an AI-based digital pathology approach, we observed pronounced fibrosis reduction in the ...