Dendritic cells (DCs) are critical in the maintenance ... They secrete increased basal levels of proinflammatory cytokines that is accompanied by increased NF-κB activation.

2013;5(6):621-637. In summary, DCs are widely affected in MDS with respect to frequencies of different subsets, maturation, cytokine secretion and induction of T-cell proliferation (Figure 2A).

A recent study carried out by a research team from the Paul-Ehrlich-Institut investigated the immunomodulating properties of ...

How did the mannosylated BSA cause SIGNR1-expressing dendritic cells to initiate tolerance? To answer this question, they decided to characterize the cytokine expression profiles of the dendritic ...

This sensitized other dendritic cells and macrophages in the tumor environment to topical imiquimod therapy, which inhibited the formation of new blood vessels via the cytokine IL12 leading to the ...

Cytokines are small proteins that serve as the fundamental chemical messengers of the immune system. They also play a key cell signaling role in stem cell biology, relaying messages that direct stem ...

Researchers at MedUni Vienna have developed a combination therapy using systemic interferon-I and topical imiquimod. Effective against local tumors and distant metastases, the therapy improves ...