Catechol-O-methyltransferase (COMT) is an enzyme that plays a crucial role in the metabolism of catecholamine neurotransmitters, including dopamine. This makes COMT inhibitors a significant area ...
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A new class of antivirals could help prevent future pandemicsTuschl suspected that viruses would be less likely to dodge a combination therapy that targeted two unrelated viral enzymes at once, such as a protease inhibitor alongside a methyltransferase ...
Shanghaitech University has identified thiazolidinedione compounds acting as DNA methyltransferase 3A (DNMT3A) inhibitors reported to be useful for the treatment of acute myeloid leukemia and ...
Earlier studies had suggested that these drugs, known as DNA methyltransferase inhibitors (DNMTis), worked by triggering the expression of tumor suppressor genes. But Chiappinelli, then a postdoctoral ...
The global Parkinson’s disease (PD) market is expected to grow to $7.9 billion by 2033 from $3.4 billion in 2023, according ...
The market for Parkinson’s disease (PD) drugs across the seven major geographies (7MM; USA, France, Germany, Italy, UK and ...
The AptaFluor SAH Methyltransferase Assay uses a highly ... to-use and HTS-ready assay designed for screening and profiling inhibitors. The assay can be used to: ...
A DNA methyltransferase inhibitor and all-trans retinoic acid reduce oral cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide. Triterpenoids CDDO-methyl ester or CDDO-ethyl ...
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