Fatty liver disease, the excessive lipid accumulation in the liver, is a frequent metabolic condition that can progress in cancer. Despite years of research, targeted treatments are still lacking and ...

We hypothesized that using mRNA and siRNA simultaneously could restore tumor suppressors and inhibit drivers of tumor growth, such as PTEN and AR respectively, in patients with PCa. We used lipid ...

We used lipid nanoparticles to deliver mRNA and siRNA to human PCa cells to evaluate our technique’s ability to both restore the lost PTEN and silence the overexpressed AR. Our strategy could ...