Some symptoms of advanced systemic mastocytosis include headache, diarrhea, hypotension, and more. Doctors may order various tests to diagnose the condition and advise on a suitable treatment plan.

When triggered, mast cells release chemicals like histamine and heparin, which can cause signs and symptoms similar to an allergic reaction . In systemic mastocytosis, mast cells multiply ...

Systemic mastocytosis (SM) is characterized by an abnormal accumulation of mast cells, a type of immune cell present throughout the body that contributes to allergic and inflammatory responses ...

H1 antihistamines such as diphenhydramine, hydroxyzine, doxepin, loratadine, fexofenadine, or cetirizine may be used to treat symptoms of mastocytosis. Diphenhydramine, hydroxyzine, and doxepin ...