A typical human pregnancy lasts 40 weeks, but most parents know this number is only a rough estimate. Babies are born on a seemingly unpredictable timeline, with a normal pregnancy ranging from 38 to ...

Inhibition of IL-8 can significantly reduce NETosis (Abrams et al., 2019). Histones can activate neutrophils to form a network, and recombinant thrombomodulin (rTM) can inhibit the formation of NETs ...

Genes 8, 104. Kundakovic M (2017 ... Practical Guidelines for High-resolution Epigenomic Profiling of Nucleosomal Histones in Postmortem Human Brain Tissue. Biol Psychiatry 81(2):162-170. Peter CJ*, ...

As well as being essential in the precise packaging of DNA into the space of the nucleus, histone proteins are also the site ...

With the strong associations established in epidemiologic studies and a dearth of evidence on the actual mechanisms by which ...

KDM6B works by removing methyl chemical groups from histones—structures that help organize and package DNA within cells. In response to KDM6B, DNA becomes more accessible to other factors that ...

Histone post-translational modifications are covalent modifications of histones by phosphorylation on serine or threonine residues, methylation on lysine or arginine, acetylation and deacetylation ...

When DNA is tightly wrapped around proteins called histones, the genes stay off. But if the histone proteins have certain chemical modifications, or epigenetic states, it becomes looser and easier ...