More likely, particularly in C1-INH deficiency, heightened release of anaphylatoxins ... Sushi domain-containing protein 4 (SUSD4) is a complement control protein that, due to alternative splicing, ...

The fusion protein Arcalyst (rilonacept ... a condition caused by a deficiency in C1 esterase inhibitor, which normally dampens the complement cascade. CSL Behring, of King of Prussia ...

Our immune system is armed with an array of defenses designed to detect and eliminate harmful threats. One of its most powerful defense mechanisms is the complement system-a group of proteins that ...

Researchers discovered a previously unknown mechanism that may drive tissue damage and a new target for drug discovery.

The central component of the complement system is C3. The activation of each of the three pathways (CP, LP, and AP) results in cleavage of inactive C3 protein into the functional fragments C3a and C3b ...

that is investigating the relationships between circulating levels of complement proteins and geographic atrophy secondary to AMD, and is intended to help design clinical trials for CTx001.

[54] In general, IgM antibodies are more potent activators of complement than are IgG antibodies, but the prognostic relevance of AQP4-IgM in NMO has yet to be evaluated.

To join the four DNA ends, the RAG complex cooperates with ubiquitously expressed DNA repair proteins essential for non-homologous end-joining (NHEJ) (reviewed in Ref. 91). The core components of ...

This depends on the type of enzyme. The enzyme pepsin breaks down proteins in the acidic conditions of the stomach. Pepsin has an optimum of pH 2.5 and a working range of between pH 1-4.