2013;5(6):621-637. In summary, DCs are widely affected in MDS with respect to frequencies of different subsets, maturation, cytokine secretion and induction of T-cell proliferation (Figure 2A).

and dendritic cell therapy-mediated immunotherapy. oAd/APP complex induced high level of pro-inflammatory cytokine expression in vitro. Both intratumorally and intravenously administered oAd/APP ...

Methods: Donor mouse bone marrow-derived dendritic cells (BMDCs ... 3.4 DC-DAI-RNAi promotes Treg cell differentiation and induces immunosuppressive cytokines secretion in vivo We tested the ...

Stationed within the meninges, squads of immune cells lie in wait, ready to unleash an inflammatory assault within the brain if needed. Holding these trigger-happy troops back during peacetime falls ...

MSCs regulate many effector functions of innate immune cells, such as antigen presentation by dendritic cells (DCs ... the release of pro-inflammatory cytokines and promote the survival of ...

Gene therapies to treat rheumatoid arthritis have evolved slowly, but one is ready to move into human trials and an ...

New research reveals that brain cells use a muscle-like signaling mechanism to relay information over long distances.

Monoallelic loss of PTEN and ARID1A is identified in normal colonic epithelium. The resulting haploinsufficient phenotypes ...

The management of Leishmania donova ni (LD), responsible for fatal visceral leishmaniasis (VL), faces increasing challenges due to rising drug-unresponsiveness, leading to increasing treatment ...

Jan. 31, 2025 — Prolonged illnesses like cancer and chronic infections often leave the immune system in a state of exhaustion, where its frontline defenders -- T cells -- lose their ability to ...

From the Center for Systems Biology (W.C.P., M.N., F.K.S.), Massachusetts General Hospital and Harvard Medical School, Boston. From the Center for Systems Biology (W ...