Over the past two decades, the idea of targeting transcription factors to combat malignancies has turned into a clinical ...

MDM2, on the other hand, is one of the most frequently studied oncogenes and is an excellent target for cancer therapy, based on its p53-dependent and p53-independent oncogenic activities in ...

A kidney cancer cell nucleus is studded with aberrant nuclear speckles (orange). Normal healthy cells tend to have the speckles clustered toward the middle. Image credit: Kate Alexander (Cold Spring ...

Therapeutic restoration of mutated p53 can restore anti-cancer immune cell infiltration and ameliorate pro-tumor signaling to induce tumor regression. Indeed, there is clinical evidence to suggest ...

The C-terminal 19 amino acids of wild type p53 suppress the p53 response at sublethal doses of radiation. In contrast to cancer cells, mutant p53 activities are not well defined in nonmalignant cells.

A common aromatic shrub that has served as traditional medicine for centuries could point the way toward innovative treatments for colorectal cancer ...