Glutamine is deaminated to form glutamate, which is processed to produce a-KG for use in the TCA cycle. HIF-1 is a heterodimeric protein ... Cell proliferation requires expanded uptake of supplements, ...

A large team of researchers working on the Alpha Magnetic Spectrometer Collaboration, which has been analyzing eleven years' ...

In this issue of Nature Metabolism, Palme et al. address the fundamental question of how metabolic flux sensing is coupled to gene expression.

Intracellular lactate inhibits glycolytic enzymes while promoting the tricarboxylic acid cycle, generating a negative feedback ... isocitrate dehydrogenase; TCA, Tricarboxylic acid; HDAC, histone ...

This study provides a valuable approach to image and analyze in vivo metabolic flux through glucose turnover kinetics in glioblastoma tumor microenvironments. The evidence for the method's validity is ...