Conclusion: Our findings provide new insights into the molecular mechanisms underlying IIRI, identify potential diagnostic biomarkers, and highlight the promise of exosome-based siRNA delivery as a ...

Unlike inclisiran’s siRNA mechanism, VERVE-101 uses an mRNA-encoded adenine base editor plus a guide RNA that specifically targets the PCSK9 gene. Base editing alters a single base pair in the ...

Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug ...

We hypothesized that using mRNA and siRNA simultaneously could restore ... We also plan to further explore the biological mechanisms underlying the combined effects we observed, which may lead ...

We used lipid nanoparticles to deliver mRNA and siRNA to human PCa cells to evaluate our technique's ability to both restore the lost PTEN and silence the overexpressed AR. Our strategy could also ...

The findings shed light on how socio-sexual preferences adapt for survival and health in mammals. Understanding these neural mechanisms could inform studies on social behavior and stress responses in ...

Key Laboratory of Eutrophication and Red Tide Prevention of Guangdong Higher Education Institutes, College of Life Science and Technology, Jinan University, Guangzhou 510632, China ...

Historically, investigations into the sensory mechanisms of olfactory receptors were often confined to behavioral characteristics in model organisms or the expression of related proteins and genes.

New mechanism discovered that triggers immune response in cells with damaged DNA. ScienceDaily . Retrieved January 31, 2025 from www.sciencedaily.com / releases / 2025 / 01 / 250106132158.htm ...

In this study, we aimed to elucidate the role and mechanisms underlying PPM1B deubiquitination in HFHSD-induced arterial stiffness. Enzymes governing PPM1B deubiquitination were identified through ...