Immunotherapy (biologic therapy) helps boost the body's immune system to fight off or destroy kidney cancer cells more effectively. Learn more here.

Sep 28, 2021 · Authorship includes a multidisciplinary group of renal carcinoma experts. This article focuses on the recent immunotherapy updates to the treatment of renal cell carcinoma (RCC) as given in the RCC: ESMO Clinical Practice …

Renal cell carcinoma is the third type of urologic cancer and has a poor prognosis with 30% of metastatic patients at diagnosis. The antiangiogenics and targeted immunotherapies led to treatment remodeling emphasizing the role of the tumour microenvironment. However, long-term responses are rare with a high rate of resistance.

Apr 5, 2020 · Renal cell carcinoma is the third type of urologic cancer and has a poor prognosis with 30% of metastatic patients at diagnosis. The antiangiogenics and targeted immunotherapies led to treatment remodeling emphasizing the role of the tumour microenvironment.

CD8 T cells are known to improve clinical outcomes and sensitivity to immunotherapy, and play a crucial role against tumors. In contrast, tumor-associated macrophages (TAMs) suppress immunity against malignancy and lead to tumor progression. TAMs are promoted from damaged TMEs and mount proinflammatory responses to pathogens.

In this editorial, we described the results of the most recent clinical trials on the use of immunotherapies in RCC and the emerging data on the research for reliable biomarkers of tumour response in this setting.

Sep 7, 2022 · Immunotherapy (IO) has significantly improved outcomes in metastatic renal cell carcinoma (mRCC). Preclinical evidence suggests that responses to IO may be potentiated via immunomodulatory effects of stereotactic radiation therapy (SRT).

Oct 13, 2023 · Tailored immunotherapy approach with nivolumab with or without nivolumab plus ipilimumab as immunotherapeutic boost in patients with metastatic renal cell carcinoma (TITAN-RCC): a multicentre, single-arm, phase 2 trial. Lancet Oncol. 2023; published online Oct 13. https://doi.org/10.1016/S1470-2045 (23)00449-7. 6.

Immunotherapy with checkpoint inhibitors has become a major modality for the treatment of clear cell RCC. This topic will discuss initial systemic therapy for advanced and metastatic clear cell RCC, with a particular focus on immunotherapy-based combinations.

Mar 12, 2023 · If you have advanced kidney cancer, also known as metastatic renal cell carcinoma, your doctor may suggest you try immunotherapy. It helps some people with the disease live longer.