For medium half-life drugs (about a day), 50% dose reduction for days 1-3 could be followed by reducing to 25% of initial dose for days 4-6, before discontinuing entirely, and all offset by the same up-taper.

Antipsychotic dose equivalents may be utilized when switching between antipsychotics or when comparing different medications. Multiple methods are used to calculate antipsychotic dose equivalences, each with their own strengths and limitations.

If initial dose >100 mg, give in 2 injections, 3-7 days apart (ex. If patient’s dose is 250mg, give 100 mg on day 1, then remaining 150 mg 3-7 days later)

The dose may be adjusted up to 600 mg/day in increments of 100 mg/day depending on clinical response and tolerability. For acute mania, immediate-release quetiapine should be administered twice daily. A recommended regimen to introduce quetiapine is: 100 mg on day 1; 200 mg on day 2; 300 mg on day 3; 400 mg on day 4.

Multiply the total daily dose by 15 to 20 (to a maximum of 300mg) and administer every 4 weeks. Decrease the dose by 25% each month until the minimum effective dose is achieved. Elderly or those on < 10mg per day orally should have a dose 10 to 15 times the oral dose, every 4 weeks. Accumulation occurs after approximately 3 weeks of depot therapy.

This is a dose equivalent calculator for antipsychotics. Calculator adapted from the paper: Dose Equivalents for Antipsychotic Drugs: The DDD Method (Leucht, 2016)

Mar 15, 2020 · Learn antipsychotic dose equivalents for patients switched from one medication to another due to insurance, efficacy or adverse effects.

To convert patient from a different antipsychotic to Risperdal Consta® 1. Administer test dose of po risperidone (to check for tolerance/hypersensitivity) 2. Titrate as above 3. Continue original po atypical antipsychotic X 3 wks then dc (manufacturer rec) -or- Continue original po atypical antipsychotic X 4 wks then dc (Sac County rec)

Day 1: Oral dose x 1.25. Alternative-ly, may initiate 25mg IM q2 weeks and titrate/ taper based on treatment response and tolerability. Yes. Optimally for 3-5 weeks. Can more rapidly titrate or taper due to shorter half-life, short onset to peak plasma levels (2- 5 days), lower cost. Less metabolic syndrome risk than second generation agents.

The dose equivalence of oral to LAI formulations is well defined for some but not all of the LAI options. Choosing the appropriate LAI dose is best accomplished by understanding the current extent of medication exposure—in other words, by obtaining plasma antipsychotic levels.7 Plasma antipsychotic levels should