BRAF is a component in a MAPK (ERK) signaling pathway that culminates with activation of transcription factors important for cell growth, proliferation, and survival.

With the emergence of a deeper understanding of how BRAF mutations signal through the RAS/mitogen activated protein kinase (MAPK) pathway, newer RAF inhibitors are being …

Jul 10, 2006 · Here, we demonstrate a novel role of the activated MAPK pathway in immune evasion by melanoma cells with the mutation of BRAF, which encodes a MAPKKs, (BRAF …

The BRAF gene encodes for a serine/threonine protein kinase that participates in the MAPK/ERK signalling pathway and plays a vital role in cancers and developmental syndromes …

Nov 1, 2022 · In this review, we identify the mechanics of RAF signaling through the RAS/MAPK pathway, present existing data on single-agent and combination RAF targeting efforts, …

Jan 26, 2024 · Oncogenic BRAF mutations induce MAPK signalling pathway activation and are key drivers of tumorigenesis across diverse cancer types, including melanomas, thyroid …

Dec 18, 2023 · In this review, we delve deeper into the mechanistic insights surrounding RAF kinase signaling in tumorigenesis and RAFi-resistance. Furthermore, we explore and discuss …

Jul 16, 2024 · Activating mutations in the mitogen-activated protein kinase (MAPK) pathway represent driver alterations governing tumorigenesis, metastasis, and therapy resistance. …

Nov 20, 2023 · The combination of MAPK and PI3K inhibitors reversed Braf V637E oncogene-promoted cell dedifferentiation while restoring thyroid follicle organization and function in vitro. …

Jan 3, 2024 · The mitogen-activated protein kinase (MAPK) pathway is essential for cellular proliferation, growth, and survival. Constitutive activation of this pathway by BRAF mutations …