The Structure and Dynamics of HIV Surface Spikes
Nov 3, 2014 · Scientists illuminated the movement and complete structure of the spikes that the HIV virus uses to bind to the cells it infects. The findings will help guide efforts to develop HIV …
Unexpected findings detailed in new portrait of HIV | UW News
Feb 16, 2022 · These detailed findings include 3D views of the structure and position of the virus’ envelope “spike” proteins (the Env protein, used when the virus binds with cells) in the context …
Distribution and three-dimensional structure of AIDS virus envelope spikes
May 24, 2006 · Envelope glycoprotein (Env) spikes on AIDS retroviruses initiate infection of host cells and are therefore targets for vaccine development. Though crystal structures for partial …
Assembly and Architecture of HIV - PMC - PubMed Central (PMC)
The exterior of HIV-1 virions is studded with trimeric envelope (Env) glycoprotein spikes composed of an ectodomain (gp120) and a transmembrane domain (gp41). The Env proteins …
The structural biology of HIV-1: mechanistic and therapeutic insights
The HIV-1 envelope spikes, which comprise trimers of non-covalently linked heterodimers of the surface gp120 and transmembrane gp41 glycoproteins 7–9, initiate a cascade of …
Dynamic HIV-1 spike motion creates vulnerability for its ... - Nature
Oct 27, 2022 · Vaccines targeting HIV-1’s gp160 spike protein are stymied by high viral mutation rates and structural chicanery. gp160’s membrane-proximal external region (MPER) is the …
The low spike density of HIV may have evolved because of the
Aug 30, 2018 · High spike densities (SDs) can promote infection, but spikes are also targets of antibody-mediated immune responses. Thus, diverse evolutionary pressures can influence …
Structural basis for membrane anchoring of HIV-1 envelope spike
Jun 23, 2016 · HIV-1 envelope spike (Env) is a type I membrane protein that mediates viral entry. We used nuclear magnetic resonance to determine an atomic structure of the transmembrane …
AIDS virus envelope spike structure - ScienceDirect
Apr 1, 2007 · The envelope (Env) spikes on HIV-1 and closely related SIV define the viral tropism, mediate the fusion process and are the prime target of the humoral response. Despite …
Structure of the Transmembrane Domain of HIV-1 Envelope …
Apr 1, 2021 · HIV-1 envelope spike (Env) is a heavily glycosylated, type I membrane protein that mediates fusion of viral and cell membranes to initiate infection. It is also a primary target of …